I've put on a couple of sets on 4.6 cars in the past, and yeah, it's like performing open heart surgery.
On yourself.
That being said, the Lightnings aren't too bad with shorty headers. Put the front end on jackstands, yank the wheels and splash shields, and they come out through the fenders. With as many sets of header gaskets as I've blown, I have pulling the headers on one down to an art form.