My first guess is that he has the wrong "calibration" on the MAF meter... like the injectors are too big or too small.
I've seen several foxbodies with S-trim (V1) vortechs run pretty darn well with 42# injectors and an appropriately "calibrated" MAF meter for 42# injectors. That's a great start, and then fine-tune with Quarterhorse or Tweecer.
